.Pharmacolibrary.Drugs.ATC.N.N01AX07

Information

Etomidate is a short-acting intravenous anesthetic agent used for the induction of general anesthesia and sedation for short procedures. It is known for its rapid onset and minimal cardiovascular effects, making it particularly useful in patients with hemodynamic instability. It is approved and clinically used for anesthesia induction.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects after intravenous bolus administration.

References

1. Lin, L, et al., & Zhang, MZ (2012). Population pharmacokinetics of intravenous bolus etomidate in children over 6 months of age. Paediatric anaesthesia 22(4) 318–326. DOI:10.1111/j.1460-9592.2011.03696.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/21917057

2. Su, F, et al., & Drover, DR (2015). Population pharmacokinetics of etomidate in neonates and infants with congenital heart disease. Biopharmaceutics & drug disposition 36(2) 104–114. DOI:10.1002/bdd.1924 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25377074

3. Kaneda, K, et al., & Han, TH (2011). Population pharmacokinetics and pharmacodynamics of brief etomidate infusion in healthy volunteers. Journal of clinical pharmacology 51(4) 482–491. DOI:10.1177/0091270010369242 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20498288

Revisions

• 06/2025 initial generated model