name: | Propofol |
ATC code: | N01AX10 | route: | intravenous |
n-compartments | 3 |
Propofol is a short-acting intravenous anesthetic agent used for the induction and maintenance of general anesthesia or sedation. It has a rapid onset and recovery profile. Propofol is widely approved and used in clinical practice today, mainly for procedural sedation, induction and maintenance of anesthesia, and sedation of mechanically ventilated adults in intensive care units.
Pharmacokinetic parameters reported in healthy adult volunteers after intravenous administration of a standard bolus dose.
Sahinovic, MM, et al., & Absalom, AR (2018). Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Clinical pharmacokinetics 57(12) 1539–1558. DOI:10.1007/s40262-018-0672-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30019172
Eleveld, DJ, et al., & Struys, MMRF (2018). Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation. British journal of anaesthesia 120(5) 942–959. DOI:10.1016/j.bja.2018.01.018 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29661412
Kim, SH, & Fechner, J (2022). Remimazolam - current knowledge on a new intravenous benzodiazepine anesthetic agent. Korean journal of anesthesiology 75(4) 307–315. DOI:10.4097/kja.22297 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35585830