.Pharmacolibrary.Drugs.ATC.N.N01AX14_1 .Pharmacolibrary.Drugs.ATC.N.N01AX14_1| name: | Esketamine_1 |
| ATC code: | N01AX14_1 | route: | intranasal |
| n-compartments | 2 |
Esketamine is the S-enantiomer of ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is used as an anesthetic agent and, more recently, as an antidepressant for treatment-resistant depression. Esketamine nasal spray is approved for use in adults with treatment-resistant depression in combination with another oral antidepressant.
Intranasal administration in adults with treatment-resistant depression.
Kurosawa, K, et al., & Pérez-Ruixo, C (2023). Evaluation of Ethnicity Effect on Intranasal Esketamine Pharmacokinetics by Population Pharmacokinetic Modeling Using Data From a Japanese Phase 2b Study. Clinical pharmacology in drug development 12(4) 397–406. DOI:10.1002/cpdd.1214 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36560916
Perez-Ruixo, C, et al., & Perez-Ruixo, JJ (2021). Population Pharmacokinetics of Esketamine Nasal Spray and its Metabolite Noresketamine in Healthy Subjects and Patients with Treatment-Resistant Depression. Clinical pharmacokinetics 60(4) 501–516. DOI:10.1007/s40262-020-00953-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33128208