.Pharmacolibrary.Drugs.ATC.N.N01BB01_1

Information

Bupivacaine is a long-acting amide-type local anesthetic commonly used for regional anesthesia, including epidural, spinal, and peripheral nerve block procedures. It is approved and widely used today in both medical and dental settings for pain control during and after surgical procedures.

Pharmacokinetics

Pharmacokinetic parameters following epidural administration in healthy adults.

References

1. Calder, A, et al., & Morton, NS (2012). Pharmacokinetic profiles of epidural bupivacaine and ropivacaine following single-shot and continuous epidural use in young infants. Paediatric anaesthesia 22(5) 430–437. DOI:10.1111/j.1460-9592.2011.03771.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/22211825

2. Olofsen, E, et al., & Dahan, A (2008). Population pharmacokinetic-pharmacodynamic modeling of epidural anesthesia. Anesthesiology 109(4) 664–674. DOI:10.1097/01.anes.0000334302.50559.c9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18813046

3. Chalkiadis, GA, et al., & Kelly, JJ (2005). Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age. British journal of anaesthesia 95(4) 524–529. DOI:10.1093/bja/aei218 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16100236

Revisions

• 06/2025 initial generated model