.Pharmacolibrary.Drugs.ATC.N.N01BB02

Information

Lidocaine is a local anesthetic and antiarrhythmic drug widely used for the numbing of tissue in a specific area and for treating ventricular arrhythmias. It is approved for use today and commonly used in both minor surgical procedures and as an intravenous therapy for cardiac arrhythmias.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after intravenous bolus administration.

References

1. Foong, KW, et al., & Loh, PS (2024). Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review. Clinical pharmacokinetics 63(5) 623–643. DOI:10.1007/s40262-024-01373-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38703307

2. Heath, C, et al., & Sommerfield, D (2023). Perioperative intravenous lidocaine use in children. Paediatric anaesthesia 33(5) 336–346. DOI:10.1111/pan.14608 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36424875

3. Crouch, CE, et al., & Fernandez-Bustamante, A (2023). Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation. Anesthesiology 138(1) 71–81. DOI:10.1097/ALN.0000000000004422 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36512707

Revisions

• 06/2025 initial generated model