.Pharmacolibrary.Drugs.ATC.N.N01BB09

Information

Ropivacaine is a long-acting local anesthetic of the amide type, mainly used for surgical anesthesia, postoperative pain management, and acute pain control (e.g., epidural, nerve block, infiltration). It is approved and widely used globally due to its lower cardiotoxicity compared to bupivacaine.

Pharmacokinetics

Pharmacokinetic parameters reported from adult healthy volunteers following intravenous administration.

References

1. Borsuk, A, et al., & Wiczling, P (2017). Flip-Flop Phenomenon in Epidural Sufentanil Pharmacokinetics: A Population Study in Children and Infants. Journal of clinical pharmacology 57(9) 1194–1206. DOI:10.1002/jcph.912 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28510304

2. Olofsen, E, et al., & Dahan, A (2008). Population pharmacokinetic-pharmacodynamic modeling of epidural anesthesia. Anesthesiology 109(4) 664–674. DOI:10.1097/01.anes.0000334302.50559.c9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18813046

3. Mossetti, V, et al., & Ivani, G (2012). Local anesthetis and adjuvants in pediatric regional anesthesia. Current drug targets 13(7) 952–960. DOI:10.2174/138945012800675713 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22512395

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)