.Pharmacolibrary.Drugs.ATC.N.N02AA01

Information

Morphine is a potent opioid analgesic derived from opium and is primarily used for the relief of moderate to severe pain. It acts as an agonist at the mu-opioid receptor and is widely used in both acute and chronic pain management, including post-surgical, cancer, and palliative care settings. Morphine is an approved drug and is currently utilized globally for its analgesic properties.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects after intravenous administration.

References

1. Lugo, RA, & Kern, SE (2002). Clinical pharmacokinetics of morphine. Journal of pain & palliative care pharmacotherapy 16(4) 5–18. DOI:10.1080/j354v16n04_02 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14635822

2. Brokjær, A, et al., & Drewes, AM (2015). Population pharmacokinetics of morphine and morphine-6-glucuronide following rectal administration--a dose escalation study. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 68 78–86. DOI:10.1016/j.ejps.2014.12.004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25486331

3. Ihmsen, H, et al., & Jeleazcov, C (2021). Pharmacokinetics of Morphine and Morphine-6-Glucuronide During Postoperative Pain Therapy in Cardiac Surgery Patients. European journal of drug metabolism and pharmacokinetics 46(2) 249–263. DOI:10.1007/s13318-020-00663-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/33547559

Revisions

• 06/2025 initial generated model