.Pharmacolibrary.Drugs.ATC.N.N02AA03

Information

name:Hydromorphone
ATC code:N02AA03
route:oral
n-compartments1

Hydromorphone is a potent opioid analgesic used to relieve moderate to severe pain. It acts primarily as a mu-opioid receptor agonist and is approved for use in many countries. Hydromorphone is available in various formulations including oral, intravenous, and rectal preparations. It is commonly used in both acute and chronic pain management, particularly in hospital settings.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers following a single oral dose.

References

  1. Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834

  2. Nakatani, T, et al., & Saito, Y (2023). Steady-State Pharmacokinetics of Intravenous Hydromorphone in Japanese Patients With Renal Impairment and Cancer Pain. Journal of palliative medicine 26(6) 768–775. DOI:10.1089/jpm.2022.0289 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36579915

  3. Rodieux, F, et al., & Samer, CF (2022). Hydromorphone Prescription for Pain in Children-What Place in Clinical Practice?. Frontiers in pediatrics 10 842454–None. DOI:10.3389/fped.2022.842454 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35547539

Revisions


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