.Pharmacolibrary.Drugs.ATC.N.N02AA55 .Pharmacolibrary.Drugs.ATC.N.N02AA55| name: | OxycodoneAndNaloxone |
| ATC code: | N02AA55 | route: | oral |
| n-compartments | 2 |
Oxycodone and naloxone (ATC N02AA55) is a fixed-dose combination opioid analgesic used for the management of severe pain, particularly in patients requiring long-term opioid therapy where opioid-induced constipation is a concern. Oxycodone acts primarily as a μ-opioid receptor agonist, while naloxone is a competitive opioid antagonist included to counteract opioid-induced constipation by local action in the gut. The oral combination is approved and used widely in clinical practice.
Pharmacokinetic parameters following repeated oral administration in healthy adults; mean values are primarily from published population PK studies of oxycodone/naloxone prolonged-release tablets.
Mercadante, S, & Giarratano, A (2013). Combined oral prolonged-release oxycodone and naloxone in chronic pain management. Expert opinion on investigational drugs 22(1) 161–166. DOI:10.1517/13543784.2013.752460 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23215628
Smith, K, et al., & Reimer, K (2008). Single- and multiple-dose pharmacokinetic evaluation of oxycodone and naloxone in an opioid agonist/antagonist prolonged-release combination in healthy adult volunteers. Clinical therapeutics 30(11) 2051–2068. DOI:10.1016/j.clinthera.2008.11.008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19108793