.Pharmacolibrary.Drugs.ATC.N.N02AJ19 .Pharmacolibrary.Drugs.ATC.N.N02AJ19| name: | OxycodoneAndIbuprofen | |
| ATC code: | N02AJ19 | route: | oral |
| compartments: | 1 | |
| dosage: | 5 | mg |
| volume of distribution: | 200 | L |
| clearance: | 40 | L/h |
| other parameters in model implementation | ||
A fixed-dose combination of oxycodone, an opioid analgesic, and ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), used for the management of moderate to severe acute pain where treatment with both opioids and NSAIDs is appropriate. Typically approved in specific countries for short-term use when other analgesic treatments are insufficient.
Estimated pharmacokinetic parameters for a typical healthy adult following oral administration of a single dose combination tablet; no original published population PK study exists for the fixed combination, so values are based on published single-compound PK data combined and adjusted for usual fixed-dose tablet ratios (e.g., 5 mg oxycodone/400 mg ibuprofen).
Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834