.Pharmacolibrary.Drugs.ATC.N.N02AX02

Information

name:Tramadol
ATC code:N02AX02
route:oral
n-compartments2

Tramadol is an opioid analgesic used for the management of moderate to moderately severe pain in adults. It is a centrally acting analgesic that binds to mu-opioid receptors and also inhibits the reuptake of norepinephrine and serotonin. Tramadol is widely approved and used today in clinical practice for pain management.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after single oral dose.

References

  1. Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834

  2. Al-Qurain, AA, et al., & Wiese, MD (2022). Population Pharmacokinetic Model for Tramadol and O-desmethyltramadol in Older Patients. European journal of drug metabolism and pharmacokinetics 47(3) 387–402. DOI:10.1007/s13318-022-00756-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/35167052

  3. Yoo, O, et al., & Lim, LY (2022). A randomised controlled trial of a novel tramadol chewable tablet: pharmacokinetics and tolerability in children. Anaesthesia 77(4) 438–448. DOI:10.1111/anae.15650 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35083739

Revisions


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