.Pharmacolibrary.Drugs.ATC.N.N02BF01

Information

Gabapentin is an anticonvulsant medication primarily used to treat neuropathic pain and partial seizures. It is also approved for the management of postherpetic neuralgia and is widely used off-label for various pain syndromes and anxiety disorders. Gabapentin is currently approved and in clinical use in many countries.

Pharmacokinetics

Pharmacokinetic parameters derived from studies in healthy adult volunteers following a single oral dose.

References

1. Hampton, CE, et al., & Pypendop, BH (2021). Pharmacokinetics of oral and compounded intravenous gabapentin in Duroc swine (Sus Scrofa). Journal of veterinary pharmacology and therapeutics 44(5) 776–782. DOI:10.1111/jvp.12977 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33978255

2. Adrian, D, et al., & Lascelles, BDX (2018). The pharmacokinetics of gabapentin in cats. Journal of veterinary internal medicine 32(6) 1996–2002. DOI:10.1111/jvim.15313 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30307652

3. Tran, P, et al., & Lee, YB (2017). Population pharmacokinetics of gabapentin in healthy Korean subjects with influence of genetic polymorphisms of ABCB1. Journal of pharmacokinetics and pharmacodynamics 44(6) 567–579. DOI:10.1007/s10928-017-9549-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29018999

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)