.Pharmacolibrary.Drugs.ATC.N.N02CA01_2 .Pharmacolibrary.Drugs.ATC.N.N02CA01_2| name: | Dihydroergotamine_2 |
| ATC code: | N02CA01_2 | route: | oral |
| n-compartments | 2 |
Dihydroergotamine is an ergot alkaloid medication primarily used for the treatment of migraine headaches and cluster headaches. It acts as a vasoconstrictor of intracranial arteries, and as an agonist at serotonin (5-HT1) receptors. It is approved and still in use for acute migraine attacks by several regulatory agencies.
Estimated pharmacokinetic parameters for oral administration in adults, since bioavailability is extremely low and no direct population PK model reported.
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Shrewsbury, SB, et al., & Weinstein, S (2008). Randomized, double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of MAP0004 (orally-inhaled DHE) in adult asthmatics. Current medical research and opinion 24(7) 1977–1985. DOI:10.1185/03007990802160677 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18534051