.Pharmacolibrary.Drugs.ATC.N.N03AA03

Information

Primidone is a barbiturate anticonvulsant medication primarily used for the treatment of epilepsy, particularly generalized tonic-clonic and partial seizures. It is also used off-label for essential tremor. It is still approved and used today but has been largely replaced by other anticonvulsants in some countries.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adults following oral administration.

References

1. Grasela, TH, et al., & Chen, C (1999). Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy. Journal of clinical pharmacology 39(4) 373–384. DOI:10.1177/00912709922007949 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10197296

2. Perucca, E, et al., & Fuseau, E (2008). Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy. Epilepsia 49(7) 1123–1141. DOI:10.1111/j.1528-1167.2008.01665.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/18503564

3. Stephen, LJ (2003). Drug treatment of epilepsy in elderly people: focus on valproic Acid. Drugs & aging 20(2) 141–152. DOI:10.2165/00002512-200320020-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12534314

Revisions

• 06/2025 initial generated model