.Pharmacolibrary.Drugs.ATC.N.N03AB02 .Pharmacolibrary.Drugs.ATC.N.N03AB02| name: | Phenytoin |
| ATC code: | N03AB02 | route: | oral |
| n-compartments | 1 |
Phenytoin is an antiepileptic drug widely used for the treatment and prevention of seizures, particularly in the management of tonic-clonic (grand mal) and partial seizures. It stabilizes neuronal membranes and decreases seizure activity by increasing efflux or decreasing influx of sodium ions across cell membranes in the motor cortex during generation of nerve impulses. Phenytoin is approved for use in many countries and is still actively used today.
Pharmacokinetic parameters reported in adult healthy volunteers and patients with epilepsy. Sex: both male and female, age range: adults (18-65 years), without significant renal or hepatic impairment.
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