name: | Mephenytoin |
ATC code: | N03AB04 | route: | oral |
n-compartments | 1 |
Mephenytoin is an anticonvulsant medication belonging to the hydantoin class, historically used for the treatment of epilepsy and other seizure disorders. Due to the risk of severe adverse effects such as aplastic anemia, it is not commonly used or approved for clinical practice today.
Estimated pharmacokinetic parameters for adult healthy individuals, as no robust published PK parameters were found. Estimates are based on known metabolism (hepatic, CYP2C19), structural similarity to phenytoin, and limited historical reports.
Sohn, DR, et al., & Chiba, K (1992). Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clinical pharmacology and therapeutics 52(2) 160–169. DOI:10.1038/clpt.1992.125 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1505151
Wedlund, PJ, et al., & Wilkinson, GR (1985). Phenotypic differences in mephenytoin pharmacokinetics in normal subjects. The Journal of pharmacology and experimental therapeutics 234(3) 662–669. PUBMED:https://pubmed.ncbi.nlm.nih.gov/4032286
Balian, JD, et al., & Flockhart, DA (1995). The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study. Clinical pharmacology and therapeutics 57(6) 662–669. DOI:10.1016/0009-9236(95)90229-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7781266