.Pharmacolibrary.Drugs.ATC.N.N03AB05

Information

Fosphenytoin is a water-soluble prodrug of phenytoin, an antiepileptic medication used for the control of generalized tonic-clonic status epilepticus and prevention and treatment of seizures during neurosurgery. It is approved for intravenous or intramuscular use in situations where oral phenytoin is not feasible.

Pharmacokinetics

Pharmacokinetic data in healthy adult subjects, after intravenous administration; rapid conversion to phenytoin occurs in vivo. Parameters reflect fosphenytoin itself, not the phenytoin metabolite.

References

1. Tanaka, J, et al., & Kumagai, Y (2013). Population pharmacokinetics of phenytoin after intravenous administration of fosphenytoin sodium in pediatric patients, adult patients, and healthy volunteers. European journal of clinical pharmacology 69(3) 489–497. DOI:10.1007/s00228-012-1373-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22918614

2. Higuchi, K, et al., & Ieiri, I (2019). Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients. Therapeutic drug monitoring 41(5) 674–680. DOI:10.1097/FTD.0000000000000651 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31095070

3. Aweeka, FT, et al., & Alldredge, BK (1999). Pharmacokinetics of fosphenytoin in patients with hepatic or renal disease. Epilepsia 40(6) 777–782. DOI:10.1111/j.1528-1157.1999.tb00778.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/10368078

Revisions

• 06/2025 initial generated model