name: | Oxcarbazepine |
ATC code: | N03AF02 | route: | oral |
n-compartments | 1 |
Oxcarbazepine is an antiepileptic drug approved for the treatment of partial seizures in adults and children. It is a structural derivative of carbamazepine and is used as monotherapy or adjunctive therapy in epilepsy. It is currently approved and widely used in clinical practice.
Pharmacokinetic parameters reported for healthy adult volunteers after oral administration.
Yang, Q, et al., & Li, X (2023). Population pharmacokinetics of oxcarbazepine 10-monohydroxy derivative in Chinese adult epileptic patients. European journal of hospital pharmacy : science and practice 30(e1) e90–e96. DOI:10.1136/ejhpharm-2022-003357 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35787526
Li, S, et al., & Liu, Z (2024). Population pharmacokinetics and dosing optimization of perampanel in children with epilepsy: A real-world study. Epilepsia 65(6) 1687–1697. DOI:10.1111/epi.17954 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38572689
Lin, WW, et al., & Wang, CL (2019). Population pharmacokinetics of oxcarbazepine active metabolite in Chinese paediatric epilepsy patients and its application in individualised dosage regimens. European journal of clinical pharmacology 75(3) 381–392. DOI:10.1007/s00228-018-2600-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30456415