name: | AminobutyricAcid |
ATC code: | N03AG03 | route: | oral |
n-compartments | 1 |
Aminobutyric acid (specifically gamma-aminobutyric acid or GABA) is a non-protein amino acid acting as a major inhibitory neurotransmitter in the mammalian central nervous system. Aminobutyric acid derivatives have been considered for anticonvulsant and anxiolytic activities. The substance corresponding to ATC code N03AG03 is gamma-aminobutyric acid (GABA), but it is not widely approved or used in current clinical practice due to poor blood-brain barrier penetration.
No human pharmacokinetic models with clinical dosing found published for aminobutyric acid (GABA) as an administered drug. Estimates provided below are based on physicochemical properties and available indirect data.
Gould, A, & Amin, S (2024). An overview of ganaxolone as a treatment for seizures associated with cyclin-dependent kinase-like 5 deficiency disorder. Expert review of neurotherapeutics 24(10) 945–951. DOI:10.1080/14737175.2024.2385937 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39082513
Toth, C (2012). Drug safety evaluation of pregabalin. Expert opinion on drug safety 11(3) 487–502. DOI:10.1517/14740338.2012.677026 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22468635
Merlino, G, et al., & Valente, M (2010). Gabapentin enacarbil in restless legs syndrome. Drugs of today (Barcelona, Spain : 1998) 46(1) 3–11. DOI:10.1358/dot.2010.46.1.1424766 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20200691