.Pharmacolibrary.Drugs.ATC.N.N03AX09

Information

name:Lamotrigine
ATC code:N03AX09
route:oral
n-compartments1

Lamotrigine is an anticonvulsant medication primarily used to treat epilepsy and bipolar disorder. It is approved for the prevention and control of seizures and for the maintenance treatment of bipolar I disorder. Lamotrigine stabilizes neuronal membranes by inhibiting voltage-sensitive sodium channels.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects, both male and female, following oral administration of lamotrigine.

References

  1. Chan, V, et al., & Tett, SE (2001). Population pharmacokinetics of lamotrigine. Therapeutic drug monitoring 23(6) 630–635. DOI:10.1097/00007691-200112000-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11802095

  2. Yang, H, et al., & Mei, S (2024). Population Pharmacokinetics of Lamotrigine and Its N2-Glucuronide Metabolite in Chinese Patients With Epilepsy. Therapeutic drug monitoring 46(5) 649–657. DOI:10.1097/FTD.0000000000001207 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38666475

  3. Jacob, S, & Nair, AB (2016). An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs. Drugs in R&D 16(4) 303–316. DOI:10.1007/s40268-016-0148-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27766590

Revisions

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