.Pharmacolibrary.Drugs.ATC.N.N03AX11 .Pharmacolibrary.Drugs.ATC.N.N03AX11| name: | Topiramate |
| ATC code: | N03AX11 | route: | oral |
| n-compartments | 1 |
Topiramate is an anticonvulsant medication primarily used in the treatment of epilepsy and the prevention of migraines. It is approved and widely used today for partial-onset or primary generalized tonic-clonic seizures in adults and children, as well as for migraine prophylaxis.
Pharmacokinetic parameters from healthy adult subjects following oral administration. Mostly studied in both male and female individuals aged 18-55 years with normal renal function.
Elewa, M, et al., & Matar, K (2023). Population Pharmacokinetics of Topiramate in Patients with Epilepsy Using Nonparametric Modeling. Therapeutic drug monitoring 45(6) 797–804. DOI:10.1097/FTD.0000000000001143 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37798835
Jacob, S, & Nair, AB (2016). An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs. Drugs in R&D 16(4) 303–316. DOI:10.1007/s40268-016-0148-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27766590
Jovanović, M, et al., & Miljković, B (2013). Population pharmacokinetics of topiramate in adult patients with epilepsy using nonlinear mixed effects modelling. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 50(3-4) 282–289. DOI:10.1016/j.ejps.2013.07.008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23891703