.Pharmacolibrary.Drugs.ATC.N.N03AX27 .Pharmacolibrary.Drugs.ATC.N.N03AX27| name: | Ganaxolone |
| ATC code: | N03AX27 | route: | oral |
| n-compartments | 1 |
Ganaxolone is a synthetic neuroactive steroid and positive allosteric modulator of GABA-A receptors. It is developed and approved as an anticonvulsant medication for the treatment of seizures, particularly in rare epilepsy syndromes such as CDKL5 deficiency disorder. Ganaxolone acts by enhancing inhibitory neurotransmission in the central nervous system.
Pharmacokinetic data following oral administration in healthy adult volunteers and patients with refractory epilepsy.
Gould, A, & Amin, S (2024). An overview of ganaxolone as a treatment for seizures associated with cyclin-dependent kinase-like 5 deficiency disorder. Expert review of neurotherapeutics 24(10) 945–951. DOI:10.1080/14737175.2024.2385937 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39082513