.Pharmacolibrary.Drugs.ATC.N.N04BA01

Information

name:Levodopa
ATC code:N04BA01
route:oral
n-compartments2

Levodopa is a precursor of dopamine used primarily in the treatment of Parkinson's disease and parkinsonism. It is usually administered with carbidopa or benserazide to inhibit peripheral metabolism, allowing more levodopa to reach the brain. Levodopa remains an approved drug today and is a mainstay treatment for motor symptoms of Parkinson's disease.

Pharmacokinetics

Typical adult patients with Parkinson's disease, both sexes, ages 40-80 years. Pharmacokinetic parameters derived from oral administration studies.

References

  1. Nyholm, D, & Hellström, PM (2021). Effects of Helicobacter pylori on Levodopa Pharmacokinetics. Journal of Parkinson's disease 11(1) 61–69. DOI:10.3233/JPD-202298 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33164946

  2. Triggs, EJ, et al., & Baruzzi, A (1996). Population pharmacokinetics and pharmacodynamics of oral levodopa in parkinsonian patients. European journal of clinical pharmacology 51(1) 59–67. DOI:10.1007/s002280050161 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8880053

  3. Othman, AA, & Dutta, S (2014). Population pharmacokinetics of levodopa in subjects with advanced Parkinson's disease: levodopa-carbidopa intestinal gel infusion vs. oral tablets. British journal of clinical pharmacology 78(1) 94–105. DOI:10.1111/bcp.12324 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24433449

Revisions


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