.Pharmacolibrary.Drugs.ATC.N.N04BA01_1

Information

name:Levodopa_1
ATC code:N04BA01_1
route:intravenous
n-compartments2

Levodopa is a precursor of dopamine used primarily in the treatment of Parkinson's disease and parkinsonism. It is usually administered with carbidopa or benserazide to inhibit peripheral metabolism, allowing more levodopa to reach the brain. Levodopa remains an approved drug today and is a mainstay treatment for motor symptoms of Parkinson's disease.

Pharmacokinetics

Healthy adult volunteers, both sexes, after intravenous administration.

References

  1. Neef, C, & van Laar, T (1999). Pharmacokinetic-pharmacodynamic relationships of apomorphine in patients with Parkinson's disease. Clinical pharmacokinetics 37(3) 257–271. DOI:10.2165/00003088-199937030-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10511920

  2. Chan, PL, et al., & Holford, NH (2005). Importance of within subject variation in levodopa pharmacokinetics: a 4 year cohort study in Parkinson's disease. Journal of pharmacokinetics and pharmacodynamics 32(3-4) 307–331. DOI:10.1007/s10928-005-0039-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/16320098

  3. Kubica, A, et al., & Kubica, J (2021). ANalgesic Efficacy and safety of MOrphiNe versus methoxyflurane in patients with acute myocardial infarction: the rationale and design of the ANEMON-SIRIO 3 study: a multicentre, open-label, phase II, randomised clinical trial. BMJ open 11(3) e043330–None. DOI:10.1136/bmjopen-2020-043330 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33649058

Revisions


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