.Pharmacolibrary.Drugs.ATC.N.N05AA04

Information

Acepromazine is a phenothiazine derivative used primarily as a veterinary tranquilizer and sedative. It is commonly administered to dogs, cats, and horses for pre-anesthetic sedation, prevention of motion sickness, or for general tranquilization. Its use in humans is extremely rare today and primarily limited to veterinary medicine.

Pharmacokinetics

Pharmacokinetic parameters for acepromazine reported in healthy adult dogs after intravenous and intramuscular administration.

References

1. Knych, HK, et al., & Kass, PH (2018). Pharmacokinetics, pharmacodynamics, and metabolism of acepromazine following intravenous, oral, and sublingual administration to exercised Thoroughbred horses. Journal of veterinary pharmacology and therapeutics 41(4) 522–535. DOI:10.1111/jvp.12494 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29457257

2. Monteiro, ER, et al., & Monteiro, BS (2016). Effects of acepromazine-morphine and acepromazine-methadone premedication on the minimum alveolar concentration of isoflurane in dogs. Veterinary anaesthesia and analgesia 43(1) 27–34. DOI:10.1111/vaa.12265 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25880906

3. Keating, S, et al., & Edginton, A (2016). Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia. Veterinary anaesthesia and analgesia 43(1) 35–43. DOI:10.1111/vaa.12271 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25943714

Revisions

• 06/2025 initial generated model