.Pharmacolibrary.Drugs.ATC.N.N05AD08

Information

name:Droperidol
ATC code:N05AD08
route:intravenous
n-compartments2

Droperidol is a butyrophenone antipsychotic agent primarily used as an antiemetic for the prevention and treatment of postoperative nausea and vomiting, and for premedication, sedation, and induction of anesthesia. It has also been used for the management of acute agitation. Its clinical use has diminished in some regions due to concerns over QT prolongation and potential cardiac arrhythmias, but it remains approved in several countries.

Pharmacokinetics

Adult patients (both sexes), healthy volunteers, intravenous (IV) bolus administration.

References

  1. Cooper, I, et al., & Graudins, A (2018). The pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling. SAGE open medicine 6 2050312118813283–None. DOI:10.1177/2050312118813283 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30574300

  2. Grunwald, Z, et al., & Bartkowski, RR (1993). The pharmacokinetics of droperidol in anesthetized children. Anesthesia and analgesia 76(6) 1238–1242. DOI:10.1213/00000539-199306000-00010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8498660

  3. Agura, ED, et al., & Shen, DD (1995). Antiemetic efficacy and pharmacokinetics of intravenous ondansetron infusion during chemotherapy conditioning for bone marrow transplant. Bone marrow transplantation 16(2) 213–222. PUBMED:https://pubmed.ncbi.nlm.nih.gov/7581139

Revisions


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