.Pharmacolibrary.Drugs.ATC.N.N05AG02

Information

name:Pimozide
ATC code:N05AG02
route:oral
n-compartments1

Pimozide is a typical antipsychotic drug of the diphenylbutylpiperidine class, primarily used in the treatment of chronic psychotic disorders such as Tourette's syndrome and schizophrenia. Although approved for use, it is less commonly prescribed today due to the risk of severe side effects, such as QT prolongation and arrhythmias.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers following oral administration.

References

  1. Sallee, FR, et al., & Perel, JM (1987). Pharmacokinetics of pimozide in adults and children with Tourette's syndrome. Journal of clinical pharmacology 27(10) 776–781. DOI:10.1002/j.1552-4604.1987.tb02995.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3480904

  2. Yonkers, KA, et al., & Blumenthal, S (1992). Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. The American journal of psychiatry 149(5) 587–595. DOI:10.1176/ajp.149.5.587 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1575248

  3. Migdalof, BH, et al., & Janssen, PA (1979). Penfluridol: a neuroleptic drug designed for long duration of action. Drug metabolism reviews 9(2) 281–299. DOI:10.3109/03602537908993895 PUBMED:https://pubmed.ncbi.nlm.nih.gov/385274

Revisions


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