.Pharmacolibrary.Drugs.ATC.N.N05AG03 .Pharmacolibrary.Drugs.ATC.N.N05AG03| name: | Penfluridol | |
| ATC code: | N05AG03 | route: | oral |
| compartments: | 2 | |
| dosage: | 40 | mg |
| volume of distribution: | 22.5 | L |
| clearance: | 0.49 | L/h/kg |
| other parameters in model implementation | ||
Penfluridol is a long-acting oral diphenylbutylpiperidine antipsychotic drug primarily used for maintenance therapy in chronic schizophrenia and other psychoses. Its prolonged action allows for once-weekly dosing. Although once used in several countries, penfluridol is now less commonly prescribed due to the availability of newer antipsychotics with more favorable side-effect profiles.
Pharmacokinetic parameters reported for adult patients with schizophrenia after single oral doses.
Migdalof, BH, et al., & Janssen, PA (1979). Penfluridol: a neuroleptic drug designed for long duration of action. Drug metabolism reviews 9(2) 281–299. DOI:10.3109/03602537908993895 PUBMED:https://pubmed.ncbi.nlm.nih.gov/385274