.Pharmacolibrary.Drugs.ATC.N.N05AX08

Information

Risperidone is an atypical antipsychotic medication primarily used to treat schizophrenia, bipolar disorder, and irritability associated with autism. It is an approved medication commonly used in psychiatric practice for both adults and children.

Pharmacokinetics

PK model parameters reported from healthy adult volunteers after single 2 mg oral dose.

References

1. Thyssen, A, et al., & Mannaert, E (2010). Population pharmacokinetics of oral risperidone in children, adolescents and adults with psychiatric disorders. Clinical pharmacokinetics 49(7) 465–478. DOI:10.2165/11531730-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20528007

2. Laffont, CM, et al., & Nasser, AF (2014). Population pharmacokinetics and prediction of dopamine D2 receptor occupancy after multiple doses of RBP-7000, a new sustained-release formulation of risperidone, in schizophrenia patients on stable oral risperidone treatment. Clinical pharmacokinetics 53(6) 533–543. DOI:10.1007/s40262-014-0132-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24464285

3. Vermeulen, A, et al., & Ludwig, EA (2007). Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder. Journal of pharmacokinetics and pharmacodynamics 34(2) 183–206. DOI:10.1007/s10928-006-9040-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17136449

Revisions

• 06/2025 initial generated model