.Pharmacolibrary.Drugs.ATC.N.N05BA04

Information

name:Oxazepam
ATC code:N05BA04
route:oral
n-compartments1

Oxazepam is a benzodiazepine medication used primarily for the management of anxiety disorders, alcohol withdrawal symptoms, and for its sedative properties. Oxazepam acts on the central nervous system, producing anxiolytic, sedative, and muscle relaxant effects. It is approved and still used today, particularly favored due to its intermediate half-life and lack of active metabolites.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers (both sexes, ages 20-40 years) after single oral administration.

References

  1. Imbert, B, et al., & Simon, N (2016). Population Pharmacokinetics of High-Dose Oxazepam in Alcohol-Dependent Patients: Is There a Risk of Accumulation?. Therapeutic drug monitoring 38(2) 253–258. DOI:10.1097/FTD.0000000000000262 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26580099

  2. Yonkers, KA, et al., & Blumenthal, S (1992). Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. The American journal of psychiatry 149(5) 587–595. DOI:10.1176/ajp.149.5.587 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1575248

  3. Wang, LL, et al., & Yun, KM (2020). Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People. European journal of drug metabolism and pharmacokinetics 45(4) 477–485. DOI:10.1007/s13318-020-00614-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32219697

Revisions


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