.Pharmacolibrary.Drugs.ATC.N.N05BA12

Information

name:Alprazolam
ATC code:N05BA12
route:oral
n-compartments1

Alprazolam is a short-acting benzodiazepine used mainly for the management of anxiety disorders, panic disorders, and sometimes for short-term relief of symptoms of anxiety. It acts as a central nervous system depressant by potentiating the effects of gamma-aminobutyric acid (GABA). Alprazolam is approved for medical use and is commonly prescribed today but has a high potential for dependence and abuse.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers (male and female), oral administration of alprazolam.

References

  1. Grasela, TH, et al., & Smith, RB (1986). An evaluation of population pharmacokinetics in therapeutic trials. Part I. Comparison of methodologies. Clinical pharmacology and therapeutics 39(6) 605–612. DOI:10.1038/clpt.1986.107 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3709024

  2. Park, JY, et al., & Shin, JG (2006). Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy subjects. Clinical pharmacology and therapeutics 79(6) 590–599. DOI:10.1016/j.clpt.2006.02.008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16765147

  3. Wennerholm, A, et al., & Bertilsson, L (2005). Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects. European journal of clinical pharmacology 61(2) 113–118. DOI:10.1007/s00228-004-0861-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/15806426

Revisions


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