.Pharmacolibrary.Drugs.ATC.N.N05CF01 .Pharmacolibrary.Drugs.ATC.N.N05CF01| name: | Zopiclone | |
| ATC code: | N05CF01 | route: | oral |
| compartments: | 2 | |
| dosage: | 7.5 | mg |
| volume of distribution: | 104.0 | L |
| clearance: | 19.4 | L/h |
| other parameters in model implementation | ||
Zopiclone is a non-benzodiazepine hypnotic agent of the cyclopyrrolone class, commonly used for the short-term treatment of insomnia. It promotes sleep by modulating the GABA-A receptor complex and is currently an approved medication in many countries for the management of sleep disorders.
Pharmacokinetic parameters assessed in healthy adult volunteers, mixed sex, single oral dose under fasting conditions.
Fernandez, C, et al., & Farinotti, R (1993). Pharmacokinetics of zopiclone and its enantiomers in Caucasian young healthy volunteers. Drug metabolism and disposition: the biological fate of chemicals 21(6) 1125–1128. PUBMED:https://pubmed.ncbi.nlm.nih.gov/7905394