.Pharmacolibrary.Drugs.ATC.N.N05CF02 .Pharmacolibrary.Drugs.ATC.N.N05CF02| name: | Zolpidem |
| ATC code: | N05CF02 | route: | oral |
| n-compartments | 1 |
Zolpidem is a non-benzodiazepine hypnotic agent of the imidazopyridine class primarily used for the short-term treatment of insomnia. It works by enhancing the activity of gamma-aminobutyric acid (GABA) via selective agonism at the benzodiazepine-1 (omega-1) receptor subtype. Zolpidem is approved and widely used today for sleep disorders.
Pharmacokinetic parameters were reported in healthy adult volunteers (both sexes), typically aged 18-45 years, under fasting conditions after single oral dose.
Monti, JM, et al., & Pandi-Perumal, SR (2017). Zolpidem's use for insomnia. Asian journal of psychiatry 25 79–90. DOI:10.1016/j.ajp.2016.10.006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28262178
Guo, T, et al., & Yang, L (2014). Comparative pharmacokinetics of zolpidem tartrate in five ethnic populations of China. Acta pharmaceutica Sinica. B 4(2) 146–150. DOI:10.1016/j.apsb.2014.02.001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26579377
Shen, M, et al., & Xiang, P (2013). CYP3A4 and CYP2C19 genetic polymorphisms and zolpidem metabolism in the Chinese Han population: a pilot study. Forensic science international 227(1-3) 77–81. DOI:10.1016/j.forsciint.2012.08.035 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22964165