.Pharmacolibrary.Drugs.ATC.N.N05CM05

Information

Scopolamine is an anticholinergic agent used to prevent nausea and vomiting caused by motion sickness or anesthesia and surgery. It acts as a competitive antagonist of muscarinic acetylcholine receptors. Scopolamine is approved and used today, commonly administered via transdermal patches or other parenteral routes.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after intravenous administration.

References

1. Alvarez-Jimenez, R, et al., & Stevens, J (2016). Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects. British journal of clinical pharmacology 82(4) 1011–1021. DOI:10.1111/bcp.13031 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27273555

2. Hudson, RJ, et al., & Peterson, MD (2001). Pharmacokinetics of sufentanil in patients undergoing coronary artery bypass graft surgery. Journal of cardiothoracic and vascular anesthesia 15(6) 693–699. DOI:10.1053/jcan.2001.28311 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11748515

Revisions

• 06/2025 initial generated model