.Pharmacolibrary.Drugs.ATC.N.N06AA03 .Pharmacolibrary.Drugs.ATC.N.N06AA03| name: | ImipramineOxide | |
| ATC code: | N06AA03 | route: | oral |
| compartments: | 1 | |
| dosage: | 75 | mg |
| volume of distribution: | 15 | L |
| clearance: | 1000 | mL/min |
| other parameters in model implementation | ||
Imipramine oxide is a tricyclic antidepressant. It is a prodrug of imipramine, formerly used in the treatment of major depressive disorders. It is not widely used or marketed today, with limited availability.
Parameters estimated for healthy adult volunteers based on analogy with imipramine, due to lack of published pharmacokinetic studies on imipramine oxide itself.
Sjöqvist, F, & Bertilsson, L (1984). Clinical pharmacology of antidepressant drugs: pharmacogenetics. Advances in biochemical psychopharmacology 39 359–372. PUBMED:https://pubmed.ncbi.nlm.nih.gov/6380229
Abernethy, DR, et al., & Shader, RI (1984). Imipramine disposition in users of oral contraceptive steroids. Clinical pharmacology and therapeutics 35(6) 792–797. DOI:10.1038/clpt.1984.114 PUBMED:https://pubmed.ncbi.nlm.nih.gov/6734030