.Pharmacolibrary.Drugs.ATC.N.N06AA04

Information

Clomipramine is a tricyclic antidepressant primarily used for the treatment of obsessive-compulsive disorder (OCD). It is also sometimes used for depression, panic disorder, and chronic pain. Clomipramine is an approved medication and is currently used in clinical practice.

Pharmacokinetics

Pharmacokinetics from healthy adult volunteers after single oral dosing.

References

1. Lainesse, C, et al., & Doucet, M (2006). Pharmacokinetics of clomipramine and desmethylclomipramine after single-dose intravenous and oral administrations in cats. Journal of veterinary pharmacology and therapeutics 29(4) 271–278. DOI:10.1111/j.1365-2885.2006.00742.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/16846464

2. de Cuyper, HJ, et al., & de Zeeuw, RA (1981). Pharmacokinetics of clomipramine in depressive patients. Psychiatry research 4(2) 147–156. DOI:10.1016/0165-1781(81)90018-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/6939006

3. John, VA, et al., & Kemp, H (1980). Effects of age, cigarette smoking and the oral contraceptive on the pharmacokinetics of clomipramine and its desmethyl metabolite during chronic dosing. The Journal of international medical research 8 Suppl 3 88–95. PUBMED:https://pubmed.ncbi.nlm.nih.gov/7202824

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)