.Pharmacolibrary.Drugs.ATC.N.N06AA09

Information

Amitriptyline is a tricyclic antidepressant (TCA) used primarily for the treatment of major depressive disorder, as well as neuropathic pain, migraine prophylaxis, and other indications. It is an approved drug that is still used in clinical practice, though its use is sometimes limited by side effects.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers and adult patients after oral administration.

References

1. Visser, M, et al., & Boothe, DM (2015). Pharmacokinetics of Amitriptyline HCl and Its Metabolites in Healthy African Grey Parrots ( Psittacus erithacus ) and Cockatoos (Cacatua Species). Journal of avian medicine and surgery 29(4) 275–281. DOI:10.1647/2014-054 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26771316

2. Koh, A, et al., & Lim, HS (2019). Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline. Journal of clinical pharmacology 59(4) 532–540. DOI:10.1002/jcph.1344 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30452773

3. Sjöqvist, F, & Bertilsson, L (1984). Clinical pharmacology of antidepressant drugs: pharmacogenetics. Advances in biochemical psychopharmacology 39 359–372. PUBMED:https://pubmed.ncbi.nlm.nih.gov/6380229

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)