.Pharmacolibrary.Drugs.ATC.N.N06AA12

Information

Doxepin is a tricyclic antidepressant primarily used in the treatment of major depressive disorder, anxiety disorders, and insomnia. It is approved for use in several countries and is known to have antihistaminic, anticholinergic, and sedative properties. It is still in clinical use today, particularly for depression and sleep disorders.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects after oral administration of doxepin tablets.

References

1. el-Yazigi, A, & Chaleby, K (1988). Steady-state kinetics of doxepin and imipramine in Saudi patients with interethnic comparison. Psychopharmacology 95(1) 63–67. DOI:10.1007/BF00212768 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3133701

2. Kirchheiner, J, et al., & Brockmöller, J (2002). Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics 12(7) 571–580. DOI:10.1097/00008571-200210000-00010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12360109

3. Gosselin, C, & Ancill, RJ (1989). Comparative plasma levels of doxepin and desipramine in the elderly. Canadian journal of psychiatry. Revue canadienne de psychiatrie 34(9) 921–924. DOI:10.1177/070674378903400913 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2611758

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)