.Pharmacolibrary.Drugs.ATC.N.N06AX02 .Pharmacolibrary.Drugs.ATC.N.N06AX02| name: | Tryptophan | |
| ATC code: | N06AX02 | route: | oral |
| compartments: | 1 | |
| dosage: | 2000 | mg |
| volume of distribution: | 27 | L |
| clearance: | 1.8 | L/h |
| other parameters in model implementation | ||
Tryptophan is an essential amino acid used as a dietary supplement and formerly as an antidepressant or sleep aid. It is a precursor for serotonin and melatonin biosynthesis. Its use as a drug has declined due to safety concerns related to eosinophilia–myalgia syndrome in contaminated batches. It is not widely approved as a prescription medication today but is available as a supplement.
Pharmacokinetic parameters for oral L-tryptophan (dose: 2 g) in healthy adult volunteers.
Lalanne, S, et al., & Tordjman, S (2021). Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder. International journal of molecular sciences 22(3) –. DOI:10.3390/ijms22031490 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33540815
Nøhr, MK, et al., & Nielsen, CU (2015). Is oral absorption of vigabatrin carrier-mediated?. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 69 10–18. DOI:10.1016/j.ejps.2014.12.018 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25562534
Kumar, S, et al., & Mautino, MR (2020). Discovery of indoximod prodrugs and characterization of clinical candidate NLG802. European journal of medicinal chemistry 198 112373–None. DOI:10.1016/j.ejmech.2020.112373 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32422549