.Pharmacolibrary.Drugs.ATC.N.N06AX05

Information

name:Trazodone
ATC code:N06AX05
route:oral
n-compartments2

Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) used primarily as an antidepressant. It is also frequently prescribed off-label for insomnia and anxiety. Trazodone is approved for use in major depressive disorder and is available in several countries.

Pharmacokinetics

Pharmacokinetics reported in healthy adult volunteers after a single oral dose.

References

  1. Davis, JL, et al., & Medlin, E (2018). Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse. Journal of veterinary pharmacology and therapeutics 41(3) 393–401. DOI:10.1111/jvp.12477 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29333613

  2. Tucker, LE, et al., & Johnson, R (2023). Pharmacokinetic, sedative, and physiological effects of oral compounded formulations of trazodone alone or in combination with gabapentin in male cats. Journal of veterinary pharmacology and therapeutics 46(5) 300–310. DOI:10.1111/jvp.13384 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37098097

  3. Wang, J, et al., & Lan, Y (2025). Pharmacokinetics and Bioequivalence Evaluation of Trazodone Hydrochloride Sustained-Release Tablets in Healthy Chinese Volunteers. Clinical pharmacology in drug development 14(2) 177–183. DOI:10.1002/cpdd.1490 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39587861

Revisions


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