name: | Trazodone |
ATC code: | N06AX05 | route: | oral |
n-compartments | 2 |
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) used primarily as an antidepressant. It is also frequently prescribed off-label for insomnia and anxiety. Trazodone is approved for use in major depressive disorder and is available in several countries.
Pharmacokinetics reported in healthy adult volunteers after a single oral dose.
Davis, JL, et al., & Medlin, E (2018). Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse. Journal of veterinary pharmacology and therapeutics 41(3) 393–401. DOI:10.1111/jvp.12477 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29333613
Tucker, LE, et al., & Johnson, R (2023). Pharmacokinetic, sedative, and physiological effects of oral compounded formulations of trazodone alone or in combination with gabapentin in male cats. Journal of veterinary pharmacology and therapeutics 46(5) 300–310. DOI:10.1111/jvp.13384 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37098097
Wang, J, et al., & Lan, Y (2025). Pharmacokinetics and Bioequivalence Evaluation of Trazodone Hydrochloride Sustained-Release Tablets in Healthy Chinese Volunteers. Clinical pharmacology in drug development 14(2) 177–183. DOI:10.1002/cpdd.1490 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39587861