.Pharmacolibrary.Drugs.ATC.N.N06AX12

Information

name:Bupropion
ATC code:N06AX12
route:oral
n-compartments2

Bupropion is an atypical antidepressant used in the treatment of major depressive disorder and as an aid in smoking cessation. It is also used off-label for attention deficit hyperactivity disorder and as an adjunct in bipolar disorder. Bupropion is approved and commonly prescribed today.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers following a single oral dose.

References

  1. Chen, G, et al., & Nomikos, G (2018). Vortioxetine: Clinical Pharmacokinetics and Drug Interactions. Clinical pharmacokinetics 57(6) 673–686. DOI:10.1007/s40262-017-0612-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29189941

  2. Zhang, F, et al., & Li, H (2019). Population Pharmacokinetics, Safety and Tolerability of Extended-Release Bupropion and Its Three Metabolites in Chinese Healthy Volunteers. European journal of drug metabolism and pharmacokinetics 44(3) 339–352. DOI:10.1007/s13318-018-0537-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/30520001

  3. Hsieh, NH, et al., & Chiu, WA (2021). A Bayesian population physiologically based pharmacokinetic absorption modeling approach to support generic drug development: application to bupropion hydrochloride oral dosage forms. Journal of pharmacokinetics and pharmacodynamics 48(6) 893–908. DOI:10.1007/s10928-021-09778-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34553275

Revisions


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