.Pharmacolibrary.Drugs.ATC.N.N06AX62 .Pharmacolibrary.Drugs.ATC.N.N06AX62| name: | BupropionAndDextromethorphan |
| ATC code: | N06AX62 | route: | oral |
| n-compartments | 1 |
Bupropion and dextromethorphan combination is a novel investigational medication under study for the treatment of major depressive disorder and other neuropsychiatric conditions. Bupropion is an atypical antidepressant and dopamine-norepinephrine reuptake inhibitor, while dextromethorphan is an NMDA receptor antagonist and sigma-1 receptor agonist with potential antidepressant effects. The formulation is currently not broadly approved for therapeutic use.
Pharmacokinetic parameters estimated for healthy adult subjects based on available data from individual components and limited public clinical data for the combination therapy.
Gravel, S, et al., & Michaud, V (2018). Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study. BMJ open 8(2) e020922–None. DOI:10.1136/bmjopen-2017-020922 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29439084