.Pharmacolibrary.Drugs.ATC.N.N06BA04_1 .Pharmacolibrary.Drugs.ATC.N.N06BA04_1| name: | Methylphenidate_1 |
| ATC code: | N06BA04_1 | route: | oral |
| n-compartments | 1 |
Methylphenidate is a central nervous system stimulant used primarily for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is approved for use in both children and adults and remains widely prescribed today.
Pharmacokinetic parameters refer to healthy children (aged 6-12 years) after repeated oral doses of immediate-release methylphenidate.
Pierce, D, et al., & Webster, K (2010). Single- and multiple-dose pharmacokinetics of methylphenidate administered as methylphenidate transdermal system or osmotic-release oral system methylphenidate to children and adolescents with attention deficit hyperactivity disorder. Journal of clinical psychopharmacology 30(5) 554–564. DOI:10.1097/JCP.0b013e3181f0c2f6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20814325
De Hondt, L, et al., & Tommelein, E (2024). Quantification of ADHD medication in biological fluids of pregnant and breastfeeding women with liquid chromatography: a comprehensive review. Frontiers in public health 12 1437328–None. DOI:10.3389/fpubh.2024.1437328 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39171321
Park-Wyllie, L, et al., & Le Lorier, J (2016). Medication Persistence, Duration of Treatment, and Treatment-switching Patterns Among Canadian Patients Taking Once-daily Extended-release Methylphenidate Medications for Attention-Deficit/Hyperactivity Disorder: A Population-based Retrospective Cohort Study. Clinical therapeutics 38(8) 1789–1802. DOI:10.1016/j.clinthera.2016.07.001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27478110