.Pharmacolibrary.Drugs.ATC.N.N06BA12

Information

Lisdexamfetamine is a prodrug of the central nervous system stimulant dextroamphetamine. It is primarily used for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adults and is also approved for the treatment of moderate to severe binge eating disorder in adults. It is currently approved and in clinical use.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers following a single oral dose.

References

1. Boellner, SW, et al., & Zhang, Y (2010). Pharmacokinetics of lisdexamfetamine dimesylate and its active metabolite, d-amphetamine, with increasing oral doses of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: a single-dose, randomized, open-label, crossover study. Clinical therapeutics 32(2) 252–264. DOI:10.1016/j.clinthera.2010.02.011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20206783

2. Tsuda, Y, et al., & Wajima, T (2020). Population pharmacokinetic and exposure-response analyses of d-amphetamine after administration of lisdexamfetamine dimesylate in Japanese pediatric ADHD patients. Drug metabolism and pharmacokinetics 35(6) 548–554. DOI:10.1016/j.dmpk.2020.08.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33082099

3. Ermer, J, et al., & Matsuo, Y (2020). A phase 1, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of single and multiple doses of lisdexamfetamine dimesylate in Japanese and Caucasian healthy adult subjects. Neuropsychopharmacology reports 40(1) 16–29. DOI:10.1002/npr2.12082 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31765110

Revisions

• 06/2025 initial generated model