.Pharmacolibrary.Drugs.ATC.N.N06BA13 .Pharmacolibrary.Drugs.ATC.N.N06BA13| name: | Armodafinil |
| ATC code: | N06BA13 | route: | oral |
| n-compartments | 1 |
Armodafinil is a wakefulness-promoting agent approved for the treatment of excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It is the R-enantiomer of modafinil and is currently approved and used clinically for these indications.
Pharmacokinetic parameters observed in healthy adult volunteers after a single oral dose of 250 mg armodafinil.
Willavize, S, et al., & Guan, L (2017). Population Pharmacokinetic Modeling of Armodafinil and Its Major Metabolites. Journal of clinical pharmacology 57(2) 255–265. DOI:10.1002/jcph.800 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27436172
Darwish, M, et al., & Ezzet, F (2012). Armodafinil and modafinil in patients with excessive sleepiness associated with shift work disorder: a pharmacokinetic/pharmacodynamic model for predicting and comparing their concentration-effect relationships. Journal of clinical pharmacology 52(9) 1328–1342. DOI:10.1177/0091270011417825 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22039290