.Pharmacolibrary.Drugs.ATC.N.N06BC01

Information

name:Caffeine
ATC code:N06BC01
route:oral
n-compartments1

Caffeine is a central nervous system stimulant belonging to the methylxanthine class. It is widely consumed in beverages such as coffee, tea, and soft drinks and is used medically to treat apnea of prematurity in neonates. It is an approved drug and also used as a psychoactive substance for reducing fatigue and improving mental alertness.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects after single oral administration of 200 mg caffeine.

References

  1. Seng, KY, et al., & Lim, CL (2009). Population pharmacokinetics of caffeine in healthy male adults using mixed-effects models. Journal of clinical pharmacy and therapeutics 34(1) 103–114. DOI:10.1111/j.1365-2710.2008.00976.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/19125908

  2. Cornelis, MC, et al., & Chasman, DI (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular psychiatry 20(5) 647–656. DOI:10.1038/mp.2014.107 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25288136

  3. Zandvliet, AS, et al., & Beijnen, JH (2005). Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine. Basic & clinical pharmacology & toxicology 96(1) 71–79. DOI:10.1111/j.1742-7843.2005.pto960111.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/15667599

Revisions


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