.Pharmacolibrary.Drugs.ATC.N.N06DA01 .Pharmacolibrary.Drugs.ATC.N.N06DA01| name: | Tacrine |
| ATC code: | N06DA01 | route: | oral |
| n-compartments | 2 |
Tacrine is a centrally acting cholinesterase inhibitor that was used in the treatment of Alzheimer's disease. It enhances cholinergic transmission in the brain by inhibiting acetylcholinesterase. Due to concerns over hepatotoxicity and the advent of more tolerable medications, tacrine is no longer widely used or approved in most regions.
Pharmacokinetic parameters reported in healthy adult volunteers, mostly elderly (age 60-75 years), after single and multiple oral doses.
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