.Pharmacolibrary.Drugs.ATC.N.N07BA01_1

Information

name:Nicotine_1
ATC code:N07BA01_1
route:transdermal
n-compartments2

Nicotine is a potent parasympathomimetic alkaloid found in tobacco. It acts as an agonist at nicotinic acetylcholine receptors in the central and peripheral nervous system. Clinically, nicotine has been used as an aid in smoking cessation therapies in the form of patches, gums, lozenges, nasal sprays, and inhalers. It remains approved for use in various nicotine replacement therapies.

Pharmacokinetics

Healthy adult volunteer smokers administered nicotine via transdermal patch (nicotine replacement therapy).

References

  1. Olsson Gisleskog, PO, et al., & Soons, PA (2021). Nicotine Population Pharmacokinetics in Healthy Smokers After Intravenous, Oral, Buccal and Transdermal Administration. Clinical pharmacokinetics 60(4) 541–561. DOI:10.1007/s40262-020-00960-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33354734

  2. Linakis, MW, et al., & Sherwin, CMT (2017). Population pharmacokinetic model of transdermal nicotine delivered from a matrix-type patch. British journal of clinical pharmacology 83(12) 2709–2717. DOI:10.1111/bcp.13393 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28771779

  3. Sobue, S, et al., & Irie, S (2005). Effect of application sites and multiple doses on nicotine pharmacokinetics in healthy male Japanese smokers following application of the transdermal nicotine patch. Journal of clinical pharmacology 45(12) 1391–1399. DOI:10.1177/0091270005282632 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16291714

Revisions


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