.Pharmacolibrary.Drugs.ATC.N.N07BA03 .Pharmacolibrary.Drugs.ATC.N.N07BA03| name: | Varenicline |
| ATC code: | N07BA03 | route: | oral |
| n-compartments | 1 |
Varenicline is a partial agonist at the alpha4beta2 nicotinic acetylcholine receptor, used as a smoking cessation aid. It is approved and widely used for helping reduce nicotine craving and withdrawal symptoms in patients attempting to quit smoking.
Pharmacokinetic parameters reported in healthy adult volunteers after oral administration.
Zhao, Q, et al., & Burstein, AH (2011). Pharmacokinetics, safety, and tolerability following multiple oral doses of varenicline under various titration schedules in elderly nonsmokers. Journal of clinical pharmacology 51(4) 492–501. DOI:10.1177/0091270010370461 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20466870
Garrison, GD, & Dugan, SE (2009). Varenicline: a first-line treatment option for smoking cessation. Clinical therapeutics 31(3) 463–491. DOI:10.1016/j.clinthera.2009.03.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19393839