.Pharmacolibrary.Drugs.ATC.N.N07BB01

Information

name:Disulfiram
ATC code:N07BB01
route:oral
n-compartments1

Disulfiram is an approved oral medication primarily used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (alcohol). It inhibits the enzyme aldehyde dehydrogenase, causing unpleasant effects when alcohol is consumed. Disulfiram is still in clinical use today for this indication.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after a single oral dose.

References

  1. Foster, PM, et al., & Gray, TJ (1984). Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat. Environmental health perspectives 57 207–217. DOI:10.1289/ehp.8457207 PUBMED:https://pubmed.ncbi.nlm.nih.gov/6499806

  2. Krall, LP (1984). Glyburide (DiaBeta): a new second-generation hypoglycemic agent. Clinical therapeutics 6(6) 746–762. PUBMED:https://pubmed.ncbi.nlm.nih.gov/6439409

  3. Johnson, DJ, et al., & Valentine, WM (1996). The measurement of 2-thiothiazolidine-4-carboxylic acid as an index of the in vivo release of CS2 by dithiocarbamates. Chemical research in toxicology 9(5) 910–916. DOI:10.1021/tx960006v PUBMED:https://pubmed.ncbi.nlm.nih.gov/8828929

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos